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various malignant diseases.pdf

软件类型:国产软件 授权方式:共享软件 界面语言:简体中文 软件大。0.31 MB 运行环境:Win2003,WinXP,Win2000,Win9X 软件等级:★★★☆☆ 发布时间:2011-11-21 官方网址:http:// 演示网址:http:// 下载次数:
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Abstract Whole body hyperthermia (WBH) has been
used as an adjunctto radio-/chemotherapyin patients
with various malignant diseases. Although clear evi-
denceisstill missing,it has been hypothesized thatan
activation oftheimmunesystem mightcontributetothe
therapeutic e?ect of WBH. To examine whether a
treatment with 60-minute41.8
 C WBH asan adjunctto
chemotherapy (WBH-CT)induces an activation of T
cells, blood samples were collected at numeroustime
pointsbeforeand upto 48 h post-treatment.Theaim of
thisstudy wasto examinethee?ectof WBH-CT onthe
expression of a broad range of activation markers on
peripheral blood lymphocytes(PBL), on serum cyto-
kinesandintracellularcytokinelevelsin T cells,andthe
capacity ofthese cellsto proliferate.Immediately after
41.8
 C WBH-CT treatment,a drasticincreasein pe-
ripheralnaturalkiller(NK)cells(
P <0.05)and CD56

+

cytotoxic Tlymphocytes(CTL; P <0.01)inthepatients’
peripheralblood was observed. At5 h post-treatment,
the percentagesofboth e?ectorcelltypes had returned
to baselinelevels. Thistransient phenomenon was ac-
companied by ashortperiod ofreduced T cellactivity,
indicated by diminished serum levels ofsolubleinter-
leukin-2 receptors (sIL-2R) at 3 h post-WBH-CT

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